Also going through were Wimbledon champion and two-time US Open winner Novak Djokovic as well as Marin Cilic, the champion in New York in 2014.
Kyrgios, 23, reached the third round by seeing off France’s Pierre-Hugues Herbert 4-6, 7-6 (8/6), 6-3, 6-0.
However, the match created a huge storm after respected umpire Mohamed Lahyani lost patience with the under-performing 30th seed and climbed down from his chair to tell the Australian, trailing by a set and 0-3, to try harder.
“I want to help you,” Lahyani could be heard saying. “This isn’t you. I know that. You are great for tennis.”
A furious Herbert said that Lahyani had over-stepped the mark.
“The umpire doesn’t have to talk to him at all. The only thing he can tell him is pay attention, because if you continue like this, I’m going to give you a warning,” said the 27-year-old.
“They can tell him from the chair. He doesn’t need to go down. He doesn’t need to say the words he said on the video. That is not his job. I don’t think he’s a coach, he’s an umpire.”
Kyrgios, however, played down the incident.
“He said he liked me. I’m not sure if that was encouragement,” said the Australian who nevertheless won 19 of the last 25 games following Lahyani’s unprecedented intervention.
“He just said that it’s not a good look. I know what I was doing out there wasn’t good.”
US Open chiefs didn’t help matters by claiming Lahyani was forced to step from his chair as the crowd noise meant that Kyrgios could not hear him.
“Lahyani was concerned that Kyrgios might need medical attention,” said tournament referee Brian Earley.
“He also informed Kyrgios that if his seeming lack of interest in the match continued, that as the chair umpire, he would need to take action.”
Djokovic downed Tennys Sandgren of the United States 6-1, 6-3, 6-7 (2/7), 6-2.
“I thought I played very well for the first two and a half sets and then I just lost it mentally. I got pissed off,” said 2011 and 2015 champion Djokovic.
“I’m not happy with the way I lost concentration and composure but I managed to kind of regroup in the fourth.”
Next up for sixth seed Djokovic is either Serb compatriot Laslo Djere or Richard Gasquet of France.
German third seed Alexander Zverev made the third round for the first time in four tries after a 6-4, 6-4, 6-2 victory over French lucky loser Nicolas Mahut.
“I’m doing a lot of stuff different. I don’t go out at all,” said the 21-year-old who will next face compatriot Philipp Kohlschreiber.
Seventh seed Cilic had a second successive easy day with a 6-2, 6-0, 6-0 rout of Polish qualifier Hubert Hurkacz. Cilic hit 34 winners and 13 aces in a quickfire 79-minute win.
Wimbledon women’s champion Angelique Kerber kept her bid for a second US Open title on track, outlasting Sweden’s Johanna Larsson 6-2, 5-7, 6-4.
“I think we both really played on a really high level from the first point,” said 2016 champion Kerber who had led by a set and 5-2 at one stage.
Kerber will next take on 2010 quarter-finalist Dominika Cibulkova after the Slovakian beat Taiwan’s Hsieh Su-Wei 7-6 (7/3), 4-6, 6-4 despite being docked two points for returning late from a heat break.
Belarus 26th seed Aryna Sabalenka continued her red-hot summer by seeing off 2010 runner-up Vera Zvonareva 6-3, 7-6 (9/7).
Sabalenka, who won the New Haven tournament last week and reached the semi-finals in Cincinnati, has made the third round of a Slam for the first time.
Later Thursday, former champion Maria Sharapova plays under the Arthur Ashe Stadium lights against Sorana Cirstea of Romania.
Second seed Caroline Wozniacki, a two-time runner-up and reigning Australian Open champion, tackles Lesia Tsurenko of Ukraine.